Perio treatment may help to manage cirrhosis

The study is published ahead of print in the American Journal of Physiology--Gastrointestinal and Liver Physiology.

Cirrhosis is the presence of scar tissue on the liver. When severe, it can lead to liver failure. Complications of cirrhosis can include infections throughout the body and hepatic encephalopathy, a buildup of toxins in the brain caused by advanced liver disease. Symptoms of hepatic encephalopathy include confusion, mood changes and impaired cognitive function.

Previous research shows that people with cirrhosis have changes in gut and salivary microbiota, which can lead to gum disease and a higher risk of cirrhosis-related complications.

In addition, studies have found that people with cirrhosis have increased levels of inflammation throughout the body, which is associated with hepatic encephalopathy.