The rise in the incidence of oropharyngeal squamous cell carcinomas (OPSCCs) linked to human papillomavirus (HPV)-16 infection has become notable, surpassing cervical high-risk HPV infections by 2019. HPV-associated OPSCCs present a better prognosis compared to traditional oropharyngeal malignancies, largely due to lower correlations with chronic tobacco and alcohol use.
Despite the sexually transmitted nature of HPV-associated OPSCCs, data on sexual behaviours is sparse in cancer registries, complicating correlation studies. Notably, high-risk factors in men include recent same-sex sexual activity, with significant odds ratios noted in studies.
The authors said this context underscores the need for accessible and effective screening tools to manage the increasing OPSCC burden, especially in resource-limited settings.
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