Scientists in the States have shown that the brain responds not only when sugar touches the tongue but also when it enters the gut.
And it is this mechanism that explains why artificial sugar can never quite successfully replicate sugar.
The discovery of this specialised gut-brain circuit offers new insight into the way the brain and body evolved to seek out sugar.
As artificial sweeteners do not activate this circuit, the study also offers compelling evidence as to why these sweeteners are never quite as satisfying as the real thing.
The authors suggest this could pave the way for the creation of sweeteners that don't just trick our tongue but also our brain.
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