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New study helps tackle tooth loss and regeneration

New research published in the Journal of Dental Research has shed light on the science behind the formation of the periodontal ligament.

This improved understanding will help scientists work towards regenerating the tissues that support teeth.

The study, led by the Universities of Plymouth and Geneva, shows how a *signalling pathway called Notch, which is known to be activated in stem cells and cancer, is important for periodontal ligament development.

*A signalling pathway describes how a group of molecules in a cell work together to control one or more cell functions, such as cell division or cell death. After the first molecule in a pathway receives a signal, it activates another molecule. This process is repeated until the last molecule is activated and the cell function is carried out.

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