Research published on August 31, 2023, in Clinical Epigenetics is the first human study to reveal the biological mechanism behind the impact of fathers’ early teenage smoking on their children.
Researchers from the University of Southampton and the University of Bergen in Norway investigated the epigenetic profiles of 875 people, aged seven to 50, and the smoking behaviours of their fathers.
They found epigenetic changes at 19 sites mapped to 14 genes in the children of fathers who smoked before the age of 15. These changes in the way DNA is packaged in cells (methylation) regulate gene expression (switching them on and off) and are associated with asthma, obesity and wheezing.
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