A survey of more than 2,500 teens and young adults found that vaping nicotine and THC, the psychoactive component in marijuana, was associated with self-reported symptoms of depression and anxiety.

The use of pod-based e-cigarettes has surged among youth and young adults in recent years. A YouGov survey in July 2022 showed that vaping among children 11-17 is up from four per cent in 2020 to seven per cent in 2022. The data also revealed that the proportion of children who admit ever having tried vaping has also risen from 14 per cent in 2020 to 16 per cent in 2022.

Joy Hart, a professor of communication at the University of Louisville in Kentucky and the studies author said, “Younger people have long been vulnerable to tobacco use, may experience greater harm from nicotine and other drugs and may be targeted by tobacco advertisers and marketers,” “E-cigarette devices are still relatively new compared to other tobacco products, such as combustible cigarettes and pipes, so more research is needed to try to better understand the popularity of e-cigarettes, including reasons for vaping and the associated health risks among youth.”

The researchers, led by the American Heart Association, conducted an online survey among 2,505 teens and young adults, ages 13-24, to gauge mental health differences among nicotine-only vapers, THC-only vapers, dual vapers of both nicotine and THC and people who had never vaped any product. The study was focused on 1,921 people who had never vaped or were current vapers, defined as having vaped in the past 30 days. Of those participants, 562 individuals reported they had never vaped, 370 had vaped only nicotine, 159 had vaped only THC, and 830 were dual vapers of nicotine and THC.

The analysis of the participants’ survey responses found:

  • Approximately 70 per cent of the THC-only vapers and 60 per cent of the nicotine-only vapers and dual vapers reported experiencing anxiety symptoms — such as worries, flashbacks, panic attacks and situational anxieties— within the past week, compared to about 40 per cent of participants who had never vaped.
  • Over half of the nicotine-only vapers, THC-only vapers and dual vapers reported experiencing symptoms of depression — such as difficulty engaging in or being interested in activities normally enjoyed, whether they felt that depression interfered with their ability to do the things they needed to do at work, at school or at home and whether depression interfered with their social life and relationships — within the past week, compared to 25 per cent of non-vapers.
  • More than 50 per cent of people in all vaping groups reported having suicidal thoughts within the past 12 months, compared to only one-third of the non-users.
  • About a quarter of the dual vapers and nicotine-only vapers started vaping nicotine to calm down or feel less stressed, and one-third of participants in both groups reported that they currently vaped nicotine to cope with feelings of anxiety. In contrast, about half of THC-only vapers started vaping THC and currently vaped THC to relieve anxiety symptoms.
  • Around 20 per cent of nicotine-only vapers and dual vapers started vaping to help feel less depressed and currently vaped for this reason. About one-third of THC-only vapers started vaping THC and nearly half currently vaped TCH to feel less depressed.

Dual vapers were significantly more likely than nicotine-only vapers to indicate addiction to nicotine (defined in this study through behaviour such as waking up at night to vape). Dual vapers of nicotine and THC were also significantly more likely to say they felt less depressed after they started vaping, whereas nicotine-only vapers were more likely to report that vaping had no impact on their feelings of depression. This may be related to dual users’ stronger addiction to these products rather than the positive impacts of the products on their mental health, the researchers said.

Joy said, “Although we knew that THC was commonly vaped, we were surprised to have so many dual vapers—more than double the nicotine-only vapers. Dual use may either compound the addictive nature of vaping or attract people who are more prone to addiction, as well as have an impact on symptoms of depression. These findings suggest the importance of addressing the use of THC and the need for building resilience and coping skills for teens and young adults.”

The study had limitations: the use of cross-sectional data did not allow researchers to assess whether symptoms of anxiety and depression, as well as suicidal thoughts, were caused or exacerbated by the use of the THC and nicotine vapes, or whether the existence of those symptoms had an effect on the use of the vape products; collecting online data via a web-based panel meant that participants may not be representative of all teens and young adults; and the data were self-reported.

Rose Marie Robertson, deputy chief science and medical officer of the American Heart Association and senior author of the study, said, “When better coping skills are developed, there may be fewer temptations to try to manage anxiety symptoms and similar mental health challenges through vaping, as well as better refusal skills if offered an electronic cigarette. Increased priority on more positive behaviours to alleviate tension and manage anxiety symptoms may reduce the likelihood of vaping, possible addiction and the increased risk of negative health outcomes. There is also an urgent need for effective communication campaigns and educational programs to increase understanding among youth and young adults of the risks of using e-cigarettes.”

Future research, Robertson said, is needed to examine the long-term connections between mental health and vaping, whether nicotine-only, THC-only or both nicotine and THC.

Loren E. Wold, assistant dean for biological health research in the College of Nursing, a professor in the Colleges of Nursing and Medicine (physiology and cell biology) at The Ohio State University, said, “This study showed the striking significance of issues with mental health in users of both nicotine vapes as well as THC vapes, and as new products continue to come on the market, I think that this is something that we will continue to see. These products were developed as smoking cessation tools for those that use traditional cigarettes, so I’m very curious now what the implications are with mental health in users who are using these products to help stop smoking.”

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